Research progress on the effect of fluoride on bone marrow mesenchymal stem cells

VernacularTitle:氟化物对骨髓间充质干细胞影响的研究进展
Author: Yuhang WU ¹ ; Xigong LI ; Wenming PAN ; Qin ZHANG
Author Information

1. 山西医科大学附属运城市中心医院骨科，运城　044000
Keywords: Fluoride; Bone marrow mesenchymal stem cells; Osteogenic differentiation; Apoptosis
From: Chinese Journal of Endemiology 2024;43(2):161-164
CountryChina
Language:Chinese
Abstract: Fluorine is an important element widely present in nature, and moderate intake can prevent dental caries and promote bone development. However, long-term excessive intake can lead to fluorosis, damaging tissues or organs such as teeth, bones, heart muscle, and blood vessels. Bone marrow mesenchymal stem cells (BMSCs) play an important role in the repair process of bone injury due to their excellent multi-directional differentiation potential. Therefore, studying BMSCs is of great value in the treatment of fluorosis caused by fluoride poisoning. This article summarize the progress on the effect of fluoride on BMSCs, providing new ideas for the study of the pathogenesis and clinical treatment of fluorosis.