Synthesis and biological effects of N-hydroxy-methyl-5-bromoisatine and derivatives
- Author:
Hung Viet Tran
- Publication Type:Journal Article
- Keywords:
N-hydroxy-methyl-5-bromoisatine
- MeSH:
Bufotenin;
Anti-Bacterial Agents
- From:Pharmaceutical Journal
1999;282(10):4-5
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
By bromation of isatin 5-bromoisatin (I) was obtained. On boiling (I) with 4% formaldehyde solution for short period of time, a compound was isolated which has been characterized as N-hydroxymethyl-5-bromoisatin (II). By condensation of I with various H2N-B compounds, 6 derivatives (III-VIII) were formed. The structures of the obtained products were characterized by IR spectroscopy (II was characterized by MS, 1H.NMR). The synthesized compounds were tested for biological activities such as antibacterial and antifungal. Among these, two compounds (I, II) showed an antibacterial activity on 8 strains of bacteria. Compound VI showed an antibacterial activity on 3 strains of bacteria. Compound VI showed an antibacterial activity on 3 strains of bacteria.
