Research progress on signaling pathways related to fluoride induced spleen immune function damage
10.3760/cma.j.cn231583-20230331-00077
- VernacularTitle:氟致脾脏免疫功能损伤相关信号通路的研究进展
- Author:
Yangyang LIU
1
;
Qiaoshi ZHAO
Author Information
1. 哈尔滨医科大学中国疾病预防控制中心地方病控制中心 国家卫生健康委病因流行病学重点实验室 黑龙江省高校病因流行病学重点实验室 黑龙江省微量元素与人类健康重点实验室，哈尔滨 150081
- Keywords:
Fluoride;
Spleen;
Lymphocytes;
Immune function;
Signaling pathways
- From:
Chinese Journal of Endemiology
2023;42(11):942-946
- CountryChina
- Language:Chinese
-
Abstract:
Fluorine is widely present in nature, and long-term excessive intake of fluoride by the body can cause damages to bone tissues such as teeth and bones, as well as non bone tissues and organs such as nervous, cardiovascular, digestive and immune systems. Fluoride can cause apoptosis and autophagy of spleen lymphocytes, ultimately leading to damage to the structure and function of spleen. This article reviews the research progress of signaling pathways related to fluoride induced spleen immune function damage, in order to provide a theoretical basis for molecular mechanism study.
