Progress in the effect of fluorosis on myocardium and related molecular mechanisms
10.3760/cma.j.cn231583-20221018-00341
- VernacularTitle:氟中毒对心肌的损害作用及相关机制的研究进展
- Author:
Weiqi CAO
1
;
Xiaoying GUO
Author Information
1. 中国医科大学公共卫生学院环境卫生学教研室，沈阳 110122
- Keywords:
Fluoride poisoning;
Myocardium;
Signaling pathway;
Apoptosis
- From:
Chinese Journal of Endemiology
2023;42(11):933-937
- CountryChina
- Language:Chinese
-
Abstract:
Fluorine is an essential element widespread in nature. Appropriate concentration of fluorine is beneficial to prevent dental caries and promote the development of bones and teeth. But long-term excessive intake of fluorine can lead to fluorosis, causing dental fluorosis and skeletal fluorosis. In addition, fluorosis can also damage the structure and function of myocardium, thereby affecting human health. However, the underlying mechanism has not been thoroughly elucidated, so it is of great significance to explore its related mechanism for prevention and treatment of fluorosis. Apoptosis, Ca 2+ channel, oxidative stress, and imbalance of related cytokines all play important roles in myocardium injury caused by fluorosis. This article mainly reviews the effects of fluorosis on myocardium and its related molecular mechanisms, and proposes prospects for future research directions.
