Research progress on the relationship between blood-brain barrier integrity and arsenic-induced cognitive dysfunction
10.3760/cma.j.cn231583-20220601-00198
- VernacularTitle:血脑屏障完整性与砷致认知功能障碍关系的研究进展
- Author:
Lin CHENG
1
;
Xiaona LIU
;
Yanhui GAO
Author Information
1. 哈尔滨医科大学中国疾病预防控制中心地方病控制中心地氟病研究所，哈尔滨 150081
- Keywords:
Arsenic;
Blood-brain barrier;
Cognitive dysfunction
- From:
Chinese Journal of Endemiology
2023;42(9):763-769
- CountryChina
- Language:Chinese
-
Abstract:
Arsenic is an environmental toxicant widely present in nature, which can enter the human body through drinking water, respiration, and skin contact. The blood-brain barrier (BBB) is an important barrier that restricts the entry of toxins, metabolites, and other substances in the blood into the brain, thereby maintaining the homeostasis of the brain microenvironment. Different forms of arsenic may cross BBB in different ways, resulting in cognitive dysfunction in humans or animals. Therefore, BBB may play an important role in arsenic-induced cognitive dysfunction. This article provides a brief overview of the structure and function of the BBB, the transport mode of the BBB, experimental methods for evaluating the integrity of the BBB, and the relationship between arsenic-induced cognitive dysfunction and the integrity of the BBB. It provides reference for the subsequent search for the way arsenic passes through the BBB, and the determination of the role and mechanism of BBB damage in arsenic induced cognitive dysfunction.
