Research progress on the influence of TGF-β/Smad signaling pathway on host T cell immune responses in parasite infection
10.3760/cma.j.cn231583-20220915-00321
- VernacularTitle:寄生虫感染中TGF-β/Smad信号通路参与调控宿主T细胞免疫应答的研究进展
- Author:
Xiaoqing SUN
1
;
Wei HE
;
Biying ZHOU
Author Information
1. 遵义医科大学寄生虫学教研室，遵义 563000
- Keywords:
Parasite;
T cells;
Immune responses;
TGF-β/Smad signal pathway
- From:
Chinese Journal of Endemiology
2023;42(9):758-762
- CountryChina
- Language:Chinese
-
Abstract:
Parasitic infection are an important global public health issue, and parasites can modulate and evade host immune attacks through various ways. In recent years, studies have shown that in the process of parasite infection, transforming growth factor-β (TGF-β)/Smad signaling pathway participates in host T cell immune response, induce T cells to proliferate and differentiate towards regulatory cells (Treg) and helper T cells (Th), regulate Treg/Th17 cell balance, inhibit Th1 cell proliferation and differentiation, and play an important role in the occurrence and development of parasitic diseases and their interactions with the host. This article reviews the research progress of T cell immune responses mediated by TGF-β/Smad signaling pathway in the process of parasite infection.
