Role of inhibition of cellular foaming by lipophagy in atherosclerosis
10.3969/j.issn.1000-4718.2024.03.022
- VernacularTitle:脂噬抑制细胞泡沫化在动脉粥样硬化中作用的研究进展
- Author:
Ya JIN
1
;
Lishuang ZHANG
;
Xianglong HUANG
;
Yaolei MA
;
Jinjie LIU
;
Han ZHANG
;
Xiao LI
Author Information
1. 天津中医药大学组分中药国家重点实验室,方剂学教育部重点实验室,中医药研究院,天津 301617
- Keywords:
atherosclerosis;
lipophagy;
autophagy;
lipid metabolism
- From:
Chinese Journal of Pathophysiology
2024;40(3):564-571
- CountryChina
- Language:Chinese
-
Abstract:
Atherosclerosis is a chronic vascular inflammatory disease caused by abnormal lipid metabolism.The formation of lipid-rich foam cells acts as the initial trigger for development of atherosclerotic lesions.Recent studies have shown that lipophagy,a form of selective autophagy,can selectively degrade lipid droplets stored intracellularly and promote cholesterol efflux through the autophagic lysosomal pathway.As a result,intracellular lipid accumulation is re-duced and foaming is inhibited,making lipophagy a potential new target for current anti-atherosclerosis therapy.This arti-cle reviews the crucial role and molecular mechanism of lipophagy in the link between lipid metabolism and atherosclero-sis.Its objective is to outline the regulatory mechanism of lipophagy and present fresh insights for the treatment of athero-sclerotic diseases.
