Recent findings with regard to roles of GGA2 in vesicle transport and related diseases
10.3969/j.issn.1000-4718.2024.03.019
- VernacularTitle:GGA2在囊泡转运和相关疾病中作用的研究进展
- Author:
Yihao TAO
1
;
MUTAILIFU BAIERNA
;
Zhengfang QI
;
Changwu LIU
;
Yuan TIAN
;
Yangyang HAN
Author Information
1. 新疆医科大学基础医学院生物学教研室,新疆 乌鲁木齐 830017
- Keywords:
GGA2 protein;
vesicle transport;
cancer;
Alzheimer disease;
diabetes mellitus
- From:
Chinese Journal of Pathophysiology
2024;40(3):543-550
- CountryChina
- Language:Chinese
-
Abstract:
Cellular dysfunction caused by vesicle transport is associated with a variety of diseases.The trans-Golgi network(TGN)to endosome transport is an important pathway of vesicle transport,and its defects leading to protein balance disorders has been linked to many diseases such as cancer,neurodegenerative diseases and diabetes mellitus.Gol-gi-associated gamma-adaptin ear-containing ADP-ribosylation factor-binding protein 2(GGA2)is a crucial protein in-volved in TGN-endosomal transport.It plays a significant role in the regulation of several diseases,including cancer,Al-zheimer disease,type 2 diabetes mellitus and cerebral ischemia,by mediating protein transport with important biological significance.This article provides an overview of the molecular structure of GGA2,its role in regulating clathrin-mediated protein transport between TGN and endosomes,and its potential implications for a variety of diseases.
