Progress in mechanism and detection methods of ferrinophagy-mediated ferroptosis
10.3969/j.issn.1000-4718.2024.02.021
- VernacularTitle:铁自噬介导铁死亡机制和检测方法的研究进展
- Author:
Jie GUO
1
,
2
;
Yulong WANG
;
Fengyi MAI
;
Wentao YANG
;
Jingrong LIANG
;
Junxiang SHU
;
Chenguang LI
Author Information
1. 深圳大学医学部生物医学工程学院,医学超声关键技术国家地方联合工程实验室,广东省生物医学信息检测与超声成像重点实验室,广东 深圳 518060
2. 深圳市第二人民医院,广东 深圳 518025
- Keywords:
ferroptosis;
ferritinophagy;
ferritin;
NCOA4;
ferric ion
- From:
Chinese Journal of Pathophysiology
2024;40(2):365-374
- CountryChina
- Language:Chinese
-
Abstract:
Ferroptosis is an iron-dependent form of regulated cell death,which is distinct from apoptosis,ne-crosis,and pyroptosis.Recent studies have found that activators of ferroptosis,such as Erastin,can activate autophagy-re-lated proteins,induce the formation of autophagosomes,and ultimately release ferric ions to mediate ferroptosis.This pro-cess,called ferritinophagy,is initiated by the binding of an autophagic cargo receptor protein,nuclear receptor coactivator 4(NCOA4),to iron-laden ferritin.The transfer of NCOA4-ferritin to the lysosome by ferritinophagy results in the proteoly-sis of ferritin,and,in turn,the release of its iron content and lipid-reactive oxygen species(ROS)accumulation.Ferritin-ophagy has been closely associated with central nervous system disorders,circulatory system diseases,and cancer.Fur-thermore,the regulation mechanism of ferritinophagy is also a hot topic in the study of iron-dependent cell death process.With the in-depth study of ferritinophagy,great progress has been made in the study of key components of ferritinophagy as well as its molecular mechanisms and processes.However,a comprehensive summary of the methods for detecting ferritin-ophagy is still unclear.To further deepen the understanding of ferritinophagy and its detection methods,this review focus-es on the concept,characteristics,methods,and precautions during detection of ferritinophagy.This review provided ex-perimental reference for subsequent researchers and promoting the progress of research related to ferritinophagy.
