Progress in impact of interaction between Treponema pallidum and ma-ternal-fetal interface cells on pregnancy outcomes
10.3969/j.issn.1000-4718.2024.02.019
- VernacularTitle:梅毒螺旋体与母胎界面细胞相互作用影响妊娠结局的机制研究进展
- Author:
Shaobin HUANG
1
;
Shun XIONG
;
Zhaoping LIU
;
Xiaohong ZHANG
;
Feijun ZHAO
Author Information
1. 南华大学衡阳医学院病原生物学研究所/特殊病原体防控湖南省重点实验室,湖南 衡阳 421001
- Keywords:
Treponema pallidum;
congenital syphilis;
maternal-fetal immunity;
adverse pregnancy outcome
- From:
Chinese Journal of Pathophysiology
2024;40(2):351-357
- CountryChina
- Language:Chinese
-
Abstract:
Treponema pallidum(Tp),a common sexually transmitted pathogen,can infect the fetus via pla-cental vertical transmission,leading to congenital syphilis(CS).This infection results in adverse pregnancy outcomes,such as stillbirth,miscarriage,preterm birth,and fetal growth restriction.However,the exact pathogenesis remains un-clear.Studies indicate that patients with early syphilis primarily exhibit pro-inflammatory immune responses.The Tp has been proven to induce dysfunction in various immune cells and abnormal expression of cytokines,potentially disrupting im-mune tolerance homeostasis and leading to adverse pregnancy outcomes.Grounded in the current understanding of CS and maternal-fetal immunology by scholars both domestically and internationally,this paper provides a comprehensive review of the potential mechanisms of Tp interacting with the cells of the maternal-fetal interface,ultimately leading to adverse pregnancy outcomes.It summarizes the pathogenesis characteristics,clinical manifestations,and maternal-fetal immune responses of CS.
