Progress in mechanism of complement system involved in pathological pain
10.3969/j.issn.1000-4718.2023.00.003
- VernacularTitle:补体系统参与病理性疼痛的机制研究进展
- Author:
Yan LUO
1
;
Xuan LIANG
;
Jingran MU
;
Tao XU
;
Junwei ZENG
Author Information
1. 遵义医科大学生理学教研室,贵州 遵义 563000
- Keywords:
complement system;
pathological pain;
spinal cord;
dorsal root ganglion;
inflammation
- From:
Chinese Journal of Pathophysiology
2024;40(2):343-350
- CountryChina
- Language:Chinese
-
Abstract:
The complement system comprises intrinsic complement components,complement regulatory pro-teins,and complement receptors.Complement activation plays a role in promoting the sensitization of peripheral pain re-ceptors,enhancing immune cell activity,and participating in the regulation of axon regeneration after nerve injury.The in-teraction of the complement system contributes to the development and maintenance of pathological pain,affecting the dor-sal root ganglion neurons,spinal dorsal horn,and brain.Consequently,targeting the complement system holds promise as a therapeutic approach for neuropathic pain treatment.This paper reviews the progress in understanding the functions of the complement system and its implications in pathological pain,offering valuable insights for the future development of targeted drug therapies.
