Progress in role of mesenchymal stem cell-derived extracellular vesicles in regulating myocardial ischemia-reperfusion injury

VernacularTitle:间充质干细胞衍生的细胞外囊泡在调控心肌缺血再灌注损伤中的研究进展
Author: Jingrui TAN ¹ ; Yongxin JIANG ; Shiyuan WANG
Author Information

1. 山东中医药大学,山东济南 250000
Keywords: myocardial ischemia; reperfusion injury; mesenchymal stem cells; extracellular vehicles
From: Chinese Journal of Pathophysiology 2024;40(1):187-192
CountryChina
Language:Chinese
Abstract: Currently,revascularization is an effective rescue strategy for patients with acute myocardial infarc-tion.However,myocardial ischemia/reperfusion(I/R)injury induced by revascularization has become a significant risk factor affecting the long-term prognosis of patients with ischemic cardiomyopathy after revascularization,without precise treatment.Extracellular vehicles derived from mesenchymal stem cells are characterized by easy access,editability,and easy absorption of cells,and their application in treating myocardial I/R injury is considered valuable to study.This review focuses on the advances in research on mesenchymal stem cell-derived extracellular vehicles and their function of regulating myocardial I/R injury after natural drug intervention,hopefully offering ideas for the research of prevention and treatment of myocardial I/R injury.