Macrophage polarization in calcium oxalate nephrolithiasis:unraveling its role and influencing factors
10.3969/j.issn.1000-4718.2024.00.003
- VernacularTitle:巨噬细胞极化在草酸钙肾结石形成中作用及其影响因素的研究进展
- Author:
Weisheng LI
1
;
Chuanguo ZHANG
;
Yangdong LI
;
Wenqiang HE
Author Information
1. 河南中医药大学,河南 郑州 450003
- Keywords:
renal calculus;
inflammation;
macrophage polarization;
calcium oxalate
- From:
Chinese Journal of Pathophysiology
2024;40(1):180-186
- CountryChina
- Language:Chinese
-
Abstract:
The most prevalent kind of renal calculi,calcium oxalate(CaOx),is characterized by its propensi-ty for recurrence in the urinary system.The development of CaOx renal calculi is greatly affected by macrophage polariza-tion.Particular oxalate causes an imbalance in macrophage polarization,which skews the M1/M2 ratio and makes it easier for CaOx crystals to accumulate in the kidneys and grow into calcium plaques in the renal papilla.Notably,M2 macro-phages can prevent CaOx renal calculi by consuming crystals and reducing inflammatory stress.As a result,immunothera-peutic techniques that alter M1 and M2 macrophage polarization are extremely promising for preventing CaOx renal calcu-li.To clarify the respective roles of M1 and M2 macrophages in the formation of CaOx crystals and provide insights for de-veloping immunotherapeutic interventions against CaOx renal calculi,this review summarizes the mechanisms underlying macrophage polarization in the genesis of CaOx renal calculi.
