Mutual facilitation of Alzheimer disease and sarcopenia:roles of myokines,amyloid proteins,and other factors
10.3969/j.issn.1000-4718.2023.00.005
- VernacularTitle:阿尔茨海默病与肌肉减少症的相互促进:肌因子、淀粉样蛋白和其他因素的作用
- Author:
Linfeng CHEN
1
,
2
;
Mengxia GUO
;
Zhong LI
;
Xiaoyun HUANG
Author Information
1. 广东医科大学,广东 湛江 524023
2. 中山大学附属第六医院神经科,广东 广州 510655
- Keywords:
Alzheimer disease;
sarcopenia;
myokines;
amyloid proteins
- From:
Chinese Journal of Pathophysiology
2024;40(1):172-179
- CountryChina
- Language:Chinese
-
Abstract:
Increasing age is the most important factor for cognitive impairment.Alzheimer disease(AD)and sarcopenia are significant causes of frailty and disability in older adults.It is important to have an in-depth understanding of the relationship between sarcopenia and AD.Studies have reported that sarcopenia often disturbs the secretion of muscle factors,which may increase the risk of developing dementia.In turn,the pathological feature of dementia,such as the de-position of amyloid β-protein(Aβ),amyloid precursor protein(APP)and tau protein in peripheral neurons,may be related to a decline in muscle function.In particular,the deposition of Aβ and APP may eventually lead to movement disorders and disability.Therefore,we hypothesize that AD and sarcopenia may mutually promote each other's pathological develop-ment.This results in exacerbation of clinical and pathological damage,in which myokine and amyloid proteins play impor-tant roles.However,the interrelationship based on amyloid protein and myokine production has not been discussed in de-tail in other reviews.In this paper,we reference and discuss the studies on this topic,and review the common risk factors for sarcopenia and AD and the potential and mechanisms for mutual improvement.
