Progress in epigenetic mechanism of hyperandrogen-induced polycystic ovary syndrome

VernacularTitle:高雄激素诱导多囊卵巢综合征表观遗传机制的研究进展
Author: Mengmeng LIANG ¹ ; Yan ZHAO ; Yanxin ZHANG ; Xinxin SHAO ; Cong CHEN ; Wenqing HAO
Author Information

1. 山东中医药大学药学院,山东济南 250355
Keywords: polycystic ovary syndrome; androgen; epigenetics
From: Chinese Journal of Pathophysiology 2024;40(1):164-171
CountryChina
Language:Chinese
Abstract: Polycystic ovary syndrome(PCOS)is characterized by high heterogeneity and heredity,and its exact pathogenesis is still not clear.Some studies have shown that epigenetic disorders,such as hyperandrogen-induced methyla-tion or acetylation of lysine at different sites(K4,K9,and K27)in histone H3,methylation and demethylation modifica-tion of genes related to steroids,hormone receptors and follicular development,and transcriptional control of microRNA or long noncoding RNA,play a central role in the occurrence and development of PCOS.This article reviews the research ad-vances in epigenetic mechanisms(histone modifications,DNA methylation,and noncoding RNA)of PCOS,in order to provide a reference for the prediction and early prevention of PCOS.