Progress in role of m6A modification regulatory enzymes and their binding proteins in cell autophagy
10.3969/j.issn.1000-4718.2024.00.002
- VernacularTitle:m6A修饰调控酶及其结合蛋白在细胞自噬中作用的研究进展
- Author:
Siqi CHEN
1
;
Shuaijie GUO
;
Mingxue ZHOU
Author Information
1. 首都医科大学附属北京中医医院,北京市中医药研究所,北京 100010
- Keywords:
m6A modification;
autophagy;
methyltransferase;
demethylase;
m6A-binding proteins
- From:
Chinese Journal of Pathophysiology
2024;40(1):157-163
- CountryChina
- Language:Chinese
-
Abstract:
Autophagy is an important mechanism to maintain cellular function and metabolism,whereas ab-normal autophagy can cause the advent and worsening of various diseases.N6-Methyladenosine(m6A)RNA methylation is a reversible RNA modification,which is regulated by m6A methyltransferase,m6A demethylase and m6A-binding protein.Studies have shown that autophagy-related genes promote or attenuate autophagy level dependent on the regulation of m6A,and then participate in the process of diseases.This paper reviews the progress of m6A modification regulatory enzymes and their binding proteins in regulating cell autophagy to provide reference for future researches.
