Progress in regulation of vascular function by sphingosine-1-phosphate in atherosclerosis
10.3969/j.issn.1000-4718.2023.12.021
- VernacularTitle:1-磷酸鞘氨醇调控血管功能在动脉粥样硬化中的研究进展
- Author:
Jing WU
1
;
Yuanping SHI
Author Information
1. 苏州大学附属第三医院临床医学研究中心,江苏 常州 213003
- Keywords:
sphingosine-1-phosphate;
apolipoprotein M;
albumin;
vascular function;
endothelial barrier;
atherosclerosis
- From:
Chinese Journal of Pathophysiology
2023;39(12):2288-2295
- CountryChina
- Language:Chinese
-
Abstract:
Sphingosine-1-phosphate(S1P)is a bioactive lipid that regulates a variety of physiological processes,including immune surveillance,immune cell transport,vascular development,and cell differentiation.S1P also plays an important role in regulating vascular function and balancing endothelial barrier homeostasis.The majority of S1P mole-cules are located in their chaperone proteins,such as apolipoprotein M or albumin.The chaperone protein is also a carrier and modulator of S1P molecules,and the combination of the two can protect the S1P structure.S1P-binding chaperone pro-tein selectively activates S1P receptor in the form of a complex that opens downstream pathways by coupling with different S1P receptor targets to exert its effects in vivo.The present review elucidates the metabolism and function of S1P,as well as the effect of chaperones on its function,and clarifies the regulation of S1P in vascular activity and pathogenesis of atherosclerosis.
