Progress in function of dynamin inhibitor dynasore and its role involved in treatments of diseases
10.3969/j.issn.1000-4718.2023.12.019
- VernacularTitle:发动蛋白抑制剂dynasore的功能及在疾病治疗中的研究进展
- Author:
Zhenzhen TIAN
1
,
2
,
3
;
Zhe CHEN
;
Ping ZHU
;
Yinhong SONG
Author Information
1. 肿瘤微环境与免疫治疗湖北省重点实验室(三峡大学),湖北 宜昌 443002
2. 三峡大学感染与炎症损伤研究所,湖北 宜昌 443002
3. 三峡大学基础医学院,湖北 宜昌 443002
- Keywords:
dynasore;
dynamin;
endocytosis;
ferroptosis;
mitophagy
- From:
Chinese Journal of Pathophysiology
2023;39(12):2273-2279
- CountryChina
- Language:Chinese
-
Abstract:
Dynasore is a small molecule that inhibits the GTPase activity of dynamin and mitochondria-related proteins both in vitro and in vivo,consequently preventing bacteria and viruses from entering cells via endocytic processes,impeding infection and spread of the pathogen.Dynasore is able to participate in cell survival,proliferation and apoptosis through a variety of dynamin protein-independent mechanisms such as reducing reactive oxygen species production,inhib-iting ferroptosis,lowering dynamin-related protein 1 activity to reduce mitophagy,and deeply engaging in vascular endo-thelial growth factor pathway.Here based on the molecular mechanisms and signaling pathways of dynasore involving in diseases,this review summarizes the role of dynasore in microbial infections,neurodegenerative diseases,and tumors.
