Research update on relationship between circadian rhythm genes and colorectal cancer
10.3969/j.issn.1000-4718.2023.12.018
- VernacularTitle:昼夜节律基因与结直肠癌关系的研究进展
- Author:
Manru ZHANG
1
,
2
;
Jing ZHAO
;
Hua ZHU
Author Information
1. 扬州大学临床医学院(江苏省苏北人民医院)药学部,江苏 扬州 225001
2. 大连医科大学,辽宁 大连 116000
- Keywords:
circadian rhythm;
clock genes;
colorectal cancer
- From:
Chinese Journal of Pathophysiology
2023;39(12):2265-2272
- CountryChina
- Language:Chinese
-
Abstract:
Biological clock genes are essential for regulating various biological processes such as sleep,endo-crine metabolism,and cell proliferation and differentiation.These genes govern the circadian system with approximately 24-h cycles in all living organisms.Recent studies have focused on uncovering the connection between circadian rhythms and tumors.Although the expression of circadian rhythm genes and their proteins is stable in normal tissue cells,in tumor cells,such as colorectal cancer tissues,the expression of these genes is often abnormally up-regulated or down-regulated,which indicates a strong correlation between the abnormal expression of clock genes and the incidence and progression of cancers.In fact,the disruption of the balance of cellular metabolism,cell cycle,cell proliferation,and apoptosis due to the abnormal expression and mutation of biological clock genes can trigger the development of colorectal cancer.In addi-tion,the disrupted circadian rhythm induced by abnormal tumor cell growth can further the advancement of disease,inva-sion,and even metastasis.Our review summarizes the functions and mechanisms of prominent clock genes in the initiation and progression of colorectal cancer based on the recent studies to provide a foundation for the development of personalized chronotherapy regimes encompassing the body's innate biorhythms in standard clinical cancer treatment procedures so as to,ultimately,optimize treatment efficacy and extend patient's life expectancy.
