Research progress in animal models of sarcoidosis
10.3969/j.issn.1000-4718.2023.12.017
- VernacularTitle:结节病样肉芽肿动物模型的研究进展
- Author:
Yueyin HAN
1
,
2
;
Mengyuan LIU
;
Huaping DAI
;
Chen WANG
Author Information
1. 中国医学科学院,北京协和医学院,北京 100730
2. 中日友好医院呼吸中心呼吸与危重症医学科,国家呼吸医学中心,国家呼吸临床研究中心,中国医学科学院呼吸病学研究院,北京 100029
- Keywords:
sarcoidosis;
animal model;
pathogenesis
- From:
Chinese Journal of Pathophysiology
2023;39(12):2259-2264
- CountryChina
- Language:Chinese
-
Abstract:
Sarcoidosis is a systemic disease of unknown etiology characterized by the formation of noncaseating granulomas.Its clinical manifestations are heterogeneous,and the determinants of clinical course(such as active vs inac-tive,remission vs chronic progression,and fibrosis vs non-fibrosis)are poorly understood.Despite considerable effort over many years,the exact pathogenesis of sarcoidosis has not been fully elucidated.Animal models have made significant con-tributions to understanding the etiology and the development of this disease.In this review,we presented the clinical rele-vance of animal models in sarcoidosis,summarized the methods for constructing the models,and discussed how they have strengthened our understanding of sarcoidosis.
