Surgical margin and efficacy evaluation of barrier resection for soft tissue sarcoma of extremities in 72 cases
10.19401/j.cnki.1007-3639.2024.03.007
- VernacularTitle:72例屏障切除术治疗四肢软组织肉瘤的切缘及疗效评估
- Author:
Guolun QU
1
;
Ruming ZHANG
;
Yong CHEN
;
Xinglong QU
;
Hongqiang ZHANG
;
Hongbo WANG
;
Kangwei WANG
;
Shuai PENG
Author Information
1. 复旦大学附属肿瘤医院闵行分院肿瘤外科,上海 200240
- Keywords:
Soft tissue sarcoma;
Barrier;
Resection margin;
Limb salvage surgery
- From:
China Oncology
2024;34(3):293-298
- CountryChina
- Language:Chinese
-
Abstract:
Background and purpose:Limbs soft tissue sarcoma(STS)is a common malignant tumor,and surgical resection is the main treatment method for it.The concept of barrier made us realize the blocking effect of natural barrier on STS,and we aimed to search for tissues that can act as barrier,and to perform complete resection of surgical margins around the tissue barrier.This study aimed to investigate the feasibility,safety and prognosis of barrier resection in the treatment of limbs STS.Methods:From December 2013 to September 2016,data of 72 patients who underwent barrier resection of STS of extremities in department of oncosurgery,Minhang Branch,Fudan University Shanghai Cancer Center were retrospectively analyzed,and the resection margin was sampled.All 72 patients underwent preoperative magnetic resonance imaging(MRI)or computed tomography(CT)design,and the physiological barrier or at least 3 cm distance was found outward from the anatomical location of the tumor.And en bloc excision was performed outside this barrier or at a distance of 3 cm.The influence of postoperative pathological margin,musculoskeletal tumor society(MSTS)score and postoperative complications on the patients were analyzed.The 1-and 3-year locoregional recurrence-free survival(LRFS)rates and sarcoma-specific survival(SSS)rates were evaluated,and the influencing factors were analyzed.This study was approved by the Ethics Committee of Fudan University Shanghai Cancer Center(number:1212117-12&1212117-12-1301).Results:All patients had negative margins.The 1-and 3-year LRFS rates were 98.2%and 93.3%,respectively.The 1-and 3-year SSS rates were 98.4%and 94.2%,respectively.The mean MSTS scores were 28.3 preoperatively and 25.5 postoperatively.Surgical complications were grade 1 to 2 in 20 cases and grade 3 in 1 case,and there were no grade 4 to 5 complications.Conclusion:Based on the combination of clinical,imaging and pathology data,barrier resection,including tumor resection and functional reconstruction,can be applied to the surgical treatment of STS,with good feasibility and safety,reliable margin and satisfactory local control.
