Research progress on the role of glutamine metabolism-related proteins in tumor metastasis

VernacularTitle:谷氨酰胺代谢相关蛋白在肿瘤转移中的作用研究进展
Author: Xuerou LIU ^{1
,

2} ; Yumei YANG ; Qian ZHAO ; Xiangyu RONG ; Wei LIU ; Ruijie ZHENG ; Jinlong PANG ; Xian LI ; Shanshan LI
Author Information

1. 蚌埠医科大学药学院,安徽蚌埠 233030
2. 安徽省生化药物工程技术研究中心,安徽蚌埠 233030
Keywords: Glutamine metabolism; Tumor metastasis; Epithelial-mesenchymal transition; Targeted therapy
From: China Oncology 2024;34(1):97-103
CountryChina
Language:Chinese
Abstract: Tumor metastasis is closely related to high mortality rate of cancer.It is well known that glutamine plays an important role in the malignant progression of cancer.Notably,as an important carbon and nitrogen donor,glutamine has been found to be closely related to tumor metastasis in recent years.Glutamine is not only involved in regulating the proliferation of tumor cells,but is also closely related to the migration and invasion of tumor cells.Furthermore,various enzymes along with transporters in the metabolism of glutamine are involved in the process of tumor metastasis through different signaling pathways.This review provided a summary of the role of glutamine in tumor metastasis in recent years and proposed therapeutic targets to provide new strategies for the clinical treatment of tumor metastases.