The Hemodynamic Effects of Enhanced External Counterpulsation and Optimization of Treatment Strategies for Cerebral Ischemic Stroke
10.16156/j.1004-7220.2024.01.005
- VernacularTitle:缺血性脑卒中的体外反搏血流动力学效应及治疗策略优化
- Author:
Ke XU
1
;
Bao LI
;
Youjun LIU
;
Liyuan ZHANG
;
Ben YANG
Author Information
1. 北京工业大学 环境与生命学部, 北京 100124
- Keywords:
enhanced external counterpulsation(EECP);
hemodynamics;
numerical simulation;
wall shear stress;
cerebral ischemic stroke
- From:
Journal of Medical Biomechanics
2024;39(1):32-39
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the hemodynamic effects of enhanced external counterpulsation(EECP)on cerebral arteries with different stenoses.Methods Zero-dimensional/three-dimensional multiscale hemodynamic models of cerebral arteries with different stenoses were constructed.Numerical simulations of the EECP hemodynamics were performed under different counterpulsation modes to quantify several hemodynamic indicators of the cerebral arteries.Among them,the mean time-averaged wall shear stress(TAWSS)downstream of the stenosis was in the range of 4-7 Pa,a low percentage of TAWSS risk area,and high narrow branch flow were considered to inhibit the development of atherosclerosis and create a good hemodynamic environment.Results For cerebral arteries with 50%,60%,70%,and 80%stenosis,the hemodynamic environment was optimal in counterpulsation mode when the moment of cuff deflation was 0.5,0.6,0.7,and 0.7 s within the cardiac cycle.Conclusions For 50%stenotic cerebral arteries,the counterpulsation mode with a deflation moment of 0.5 s should be selected.For 60%stenotic cerebral arteries,the counterpulsation mode with a deflation moment of 0.6 s should be selected.For 70%or 80%stenotic cerebral arteries,the counterpulsation mode with a deflation moment of 0.7 s should be selected.As stenosis of the cerebral arteries increases,the pressure duration should be prolonged.This study provides a theoretical reference for the EECP treatment strategy for patients with ischemic stroke with different stenoses.
