Effects of External Counterpulsation on Typical Coronary Artery Diseases:A Lumped Parameter Model Study
10.16156/j.1004-7220.2024.01.004
- VernacularTitle:体外反搏对典型冠状动脉疾病作用效果的集中参数建模仿真
- Author:
Bitian WANG
1
,
2
,
3
;
Zhujun SUN
;
Yawei WANG
;
Hanhao LIU
;
Guifu WU
;
Yubo FAN
Author Information
1. 北京航空航天大学 生物与医学工程学院
2. 北京生物医学工程高精尖创新中心
3. 教育部生物力学与力生物学重点实验室, 北京 100191
- Keywords:
lumped parameter model;
coronary artery diseases;
microcirculation angina;
enhanced external counterpulsation(EECP)
- From:
Journal of Medical Biomechanics
2024;39(1):24-31
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the hemodynamic effects of enhanced external counter pulsation(EECP)on typical coronary artery disease and microcirculation angina.Methods A physiological model of the right dominant coronary artery,including the coronary conduit arteries and coronary microcirculation,was established using lumped parameter models.Pathological conditions,such as one-vessel lesions,three-vessel lesions,and microcirculation angina,were simulated.EECP intervention models were established,and the hemodynamic effects of EECP on pathological models was simulated.Results The simulation results of the coronary physiological model,pathological models,and EECP intervention model established in this study were consistent with experimental data in related literature.EECP improved coronary blood flow in all three pathological conditions.For one-vessel lesions,EECP could not recover the blood flow of left main coronary artery to a normal level after the stenosis rate reached 80%-85%.For three-vessel lesions,EECP treatment could not be used if the stenosis rate in one of the three vessels exceeded 90%.For microcirculation angina,EECP was effective when critical condition myocardial blood flow was>1.03 mL/min·g and coronary flow reserve was>1.64.Conclusions The model of coronary disease under EECP interference established in this study meets expectations,and the obtained simulation data have certain reference values for the clinical application of EECP.
