Ethical and Welfare Review in the Modeling Process of Disease Animal Models
10.16156/j.1004-7220.2024.01.001
- VernacularTitle:疾病动物模型建模过程中伦理和福利审查
- Author:
Fengying XING
1
;
Yong ZHAO
Author Information
1. 上海交通大学医学院附属第九人民医院 实验动物中心, 上海 200011
- Keywords:
disease animal models;
ethical review;
animal welfare;
model evaluation
- From:
Journal of Medical Biomechanics
2024;39(1):1-8
- CountryChina
- Language:Chinese
-
Abstract:
Disease animal model is an indispensable part of studying the pathogenesis and treatment of diseases.Review of the ethics and welfare is the necessary measure to ensure the quality of scientific research and promote the scientific and rational use of laboratory animals.In the review practice,it is found that most applicants are difficult to accurately understand the items listed in the application form and ethical principles related to items.Therefore,a practical and feasible set of ethical guidelines for animal experiments is necessary.This review focuses on the legal and ethical basis of developing oral disease animal models,and divides the methods of establishing oral disease animal models into physical methods,chemical methods,biological methods,and combined methods.It also elaborates on the ethical and welfare review points of different modeling methods and model evaluation methods.Hopefully,ethical censors and project applicants may get more understanding of ethical review for disease animal models,and ultimately improve the standardization and applicability of animal models.
