Analysis of Treatment of Renal Atrophy Complicated with Multi-site Carbapenem-resist-ant Klebsiella Pneumoniae Infection

VernacularTitle:治疗肾萎缩合并多部位耐碳青霉烯类肺炎克雷伯菌感染分析
Author: Chengjia LUO ¹ ; Jia XU ; Ni JIANG ; Zhiling YANG
Author Information

1. 湖南省人民医院,湖南师范大学附属第一医院药剂科,长沙 410024
Keywords: Polymyxin E sodium mesylate; Carbapenem-resistant Klebsiella pneumoniae; Bloodstream infection; Urinary tract infection
From: Herald of Medicine 2024;43(4):625-629
CountryChina
Language:Chinese
Abstract: Objective To analyze the treatment of renal atrophy combined with multi-site carbapenem-resistant Kleb-siella pneumoniae(CRKP)infection,and to provide a reference for clinical rational drug use for such diseases.Methods Based on practical experience and referring to the latest literature,clinical pharmacists participated in the treatment of a case of renal atrophy complicated with multi-site CRKP infection.Recommendations were made,including adjusting the usage and dosage of meropenem,combining with polymyxin E,and timely de-escalation treatment.Results After the physician adopted the sug-gestion and adjusted the treatment plan,the patient's symptoms and infection indicators returned to normal,and the infection was effectively controlled.Conclusion Polymyxin E sodium methanesulfonate combined with high-dose meropenem had good clini-cal efficacy in the treatment of urinary tract and bloodstream infections caused by CRKP.