Anti-tumor Mechanism and Clinical Application of Pseudomonas Aeruginosa-Mannose-Sensitive Hemagglutinin

VernacularTitle:铜绿假单胞菌-甘露糖敏感血细胞凝集素抗肿瘤的作用机制及临床应用
Author: Hangzhi WEI ¹ ; Fahong WU ; Mancai WANG ; Guohui XIAO ; Yinliang BAI ; Youcheng ZHANG
Author Information

1. 兰州大学第二医院普通外科,兰州 730030
Keywords: Pseudomonas aeruginosa-mannose-sensitive hemagglutinin(PA-MSHA); Mannosylation; Immunoregulation
From: Herald of Medicine 2024;43(4):588-595
CountryChina
Language:Chinese
Abstract: The application of Pseudomonas aeruginosa-mannose-sensitive hemagglutinin(PA-MSHA)in the field of an-titumors has been increasing.PA-MSHA has been found to promote tumor cell apoptosis,inhibit tumor cell invasion and migration,differentiation,and change drug resistance and epithelial-mesenchymal transformation(EMT)by inhibiting the EGFR pathway.Meanwhile,PA-MSHA also enhances the immune killing and inhibition of macrophages and T cells to tumor cells through toll-like receptors(TLRs).In this paper,we reviewed the reported anti-tumor mechanism and clinical application of PA-MSHA,suggesting that PA-MSHA may alter the glycosylation of EGFR and TLR proteins by acting on the regulatory process of the cellular mannosy-lation process.PA-MSHA can act on cell membrane proteins,including more receptors with high-mannosylation of signaling path-ways.Elucidating the deep relationship between PA-MSHA and mannosylation is of great significance for the mechanism research and clinical application of PA-MSHA.