Angiopathic Mechanisms on Diabetic Delayed Healing Wounds:Impact and Advances in Therapeutic Agents

VernacularTitle:糖尿病伤口愈合困难的血管病变机制及治疗药物研究进展
Author: Yunxiang WANG ¹ ; Bin LI ; Xiaojuan MOU ; Jianjun LIU ; Qipeng HAN ; Taowen PAN ; Jing LIU ; Yunpeng DIAO
Author Information

1. 大连医科大学药学院,大连 116044
Keywords: Diabetic ulcer; Delayed healing wound; Angiopathies; Drug combination
From: Herald of Medicine 2024;43(4):577-581
CountryChina
Language:Chinese
Abstract: The prevalence of diabetes mellitus in China has recently been increasing year by year,and spontaneous skin ulcers in diabetic patients,as one of the most serious complications,often develop on the patient's extremities represented by foot ulcers.Due to the complexity and variety of its pathogenesis,it leads to poor clinical outcomes and difficulty in healing.Thus,pa-tients often face the risk of amputation and death.Therefore,the exploration of mechanisms of the vascular pathogenesis of diabetic delayed-healing wounds and targeted screening of therapeutic agents has become a current research hotspot.Herein,in this paper,we briefly review the role of impaired angiogenesis and vascular dysfunction in diabetic skin ulcers,and the research progress of classical hypoglycemic and natural compounds against vascular lesions is preliminarily summarized to provide a theoretical basis for effective clinical treatment.