Research Advances in Traditional Chinese Medicine and Natural Products for Cancer Treatment by Targeting Ferroptosis
10.3870/j.issn.1004-0781.2024.03.014
- VernacularTitle:中药及其天然产物通过靶向铁死亡治疗癌症研究进展
- Author:
Quanhui JIAO
1
,
2
;
Lingyun ZHONG
;
Ziwen CHENG
;
Xiaobin LYU
;
Changhua ZHANG
Author Information
1. 江西中医药大学药学院,南昌 330004
2. 南昌市第一医院中心实验室,南昌 330008
- Keywords:
Traditional Chinese medicine;
Natural products;
Cancer treatment;
Targeted ferroptosis;
Drug resistance
- From:
Herald of Medicine
2024;43(3):408-413
- CountryChina
- Language:Chinese
-
Abstract:
Ferroptosis is a unique iron-dependent cell death pattern,a novel death phenotype distinct from apoptosis,va-rious forms of necrosis,and autophagy.Numerous active ingredients extracted from traditional Chinese medicine have been found to exert anti-cancer effects by inducing ferroptosis in various cancers.An increasing number of studies have found that the regulation of ferroptosis can influence the sensitivity of tumor cells to drugs and even reverse drug resistance.When combined with chemo-therapy drugs such as cisplatin,5-FU and gemcitabine,some natural products enhance cancer cells'sensitivity to chemothera-peutic drugs by inducing ferroptosis.This paper mainly summarizes traditional Chinese medicine and its natural products that can exert anti-cancer effects by inducing ferroptosis,providing new insights for cancer treatment and drug resistance reversal.Addition-ally,it contributes to exploring the potential advantages of traditional Chinese medicine,thereby expanding its scope of applica-tion.
