Systemic Treatment Strategies for Elderly Patients with Hepatocellular Carcinoma
10.3870/j.issn.1004-0781.2024.03.007
- VernacularTitle:老年肝癌患者系统治疗策略
- Author:
Yiting SUN
1
,
2
,
3
;
Zan TENG
;
Yunpeng LIU
;
Xiujuan QU
Author Information
1. 中国医科大学附属第一医院肿瘤内科,沈阳 110000
2. 辽宁省肿瘤药物与生物治疗重点实验室,沈阳 110000
3. 辽宁省恶性肿瘤临床医学研究中心,沈阳 110000
- Keywords:
Hepatocellular carcinoma patients/elderly;
Systematic treatment strategies;
Immune checkpoint inhibitors
- From:
Herald of Medicine
2024;43(3):374-379
- CountryChina
- Language:Chinese
-
Abstract:
Senescence is the major risk factor that promotes development of different stages of chronic liver diseases and is closely related to occurrence of hepatocellular carcinoma.Significant differences consist in clinicopathological features and tumor microenvironment between elderly and young patients with hepatocellular carcinoma.With rapid development of systemic therapy,immune checkpoint inhibitors combined with targeted therapy have greatly improved the prognosis of patients with advanced hepa-tocellular carcinoma.The selection of treatment decisions for elderly patients with hepatocellular carcinoma requires to consider u-nique age-related issues.Adequate communication and necessary evaluation should be carried out before making decisions.Elderly patients with hepatocellular carcinoma are speculated to benefit from combination immunotherapy based on age subgroup analysis of large clinical studies.However,data of effects and security obtained from clinical trials has certain limitations when being ap-plied in elderly populations of real world.The optimal therapeutic strategies for elderly patients with hepatocellular carcinoma still remain to be further explored in large-scale prospective clinical studies.
