Immunotherapy Strategy for Advanced Non-Small Cell Lung Cancer in the Elderly
10.3870/j.issn.1004-0781.2024.03.004
- VernacularTitle:老年晚期非小细胞肺癌免疫治疗策略
- Author:
Jiaxin YIN
1
;
Yuxiao SONG
;
Bicheng ZHANG
Author Information
1. 武汉大学人民医院肿瘤中心,武汉 430060
- Keywords:
Immune checkpoint inhibitors;
Immunotherapy;
Non-small cell lung cancer/elderly
- From:
Herald of Medicine
2024;43(3):352-359
- CountryChina
- Language:Chinese
-
Abstract:
Immunotherapy,represented by immune checkpoint inhibitors(ICIs),has significantly changed the treat-ment strategy of non-small cell lung cancer(NSCLC)and has become an important therapy for all stages of NSCLC.However,there is an urgent need for further clarification regarding ICIs for elderly patients with advanced NSCLC.Treatment strategies for ICIs were guided by assessing survival data of elderly NSCLC patients included in clinical trials.We concluded that treatment regi-mens such as ICI monotherapy,dual immunotherapy,and ICIs combined with chemotherapy could be carried out in elderly NSCLC patients with a performance status(PS)score<2.Elderly NSCLC patients treated with ICIs could achieve similar benefits as younger patients and are generally well tolerated.However,as age increases(especially above 80 years),the efficacy decreased and the incidence of immune-related adverse events(irAEs)gradually increased.Therefore,ICIs should be carefully selected for advanced NSCLC patients at an advanced age.Compared to age,PS was a key factor causing patients to be excluded from ICIs and poorer survival outcomes.In conclusion,immunotherapy in elderly patients with advanced NSCLC is extremely challenging,and many issues still need further exploration in this field.
