Literature Case Analysis of 44 Patients with Thrombocytopenia Induced by Clopidogrel
10.3870/j.issn.1004-0781.2024.02.025
- VernacularTitle:44例氯吡格雷相关性血小板减少症的文献病例分析
- Author:
Lu JIANG
1
;
Mengfan XU
;
Fan XIA
;
Jianguo ZHU
;
Cheng XIE
Author Information
1. 苏州大学附属第一医院药学部,苏州 215000
- Keywords:
Clopidogrel;
Thrombocytopenia;
Thrombotic thrombocytopenic purpura;
Adverse drug reaction;
Literature case analysis
- From:
Herald of Medicine
2024;43(2):304-308
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the characteristics of clopidogrel-associated thrombocytopenia to provide references for clinically safe drug use.Methods The case reports of thrombocytopenia induced by clopidogrel published in PubMed,Embase,CNKI,Wanfang and VIP were searched from the establishment of each database to November 2022,and their occurrence was collated and analysed.Results A total of 44 cases from 43 articles were identified and included in the analysis.There were 30 males(68.2％)and 14 females(31.8％).Ages ranged from 37 to 88(65.0±11.4)years,of which 30(68.2％)were ≥60 years old.Thrombocytopenia was found from 8 h to 9 months after medication,of which 29 cases(65.9％)appeared within two weeks.There were 31 cases(70.5％)with severe thrombocytopenia and 38 cases(86.4％)with complications,of which 24 cases(63.2％)with bleeding and 19 cases(50.0％)with thrombotic thrombocytopenic purpura(TTP).The platelet countof41 cases(93.2％)returned to normal after drug withdrawal and symptomatic treatment,and 3 cases(6.8％)died finally.Conclusion Clopidogrel related thrombocytopenia is mainly severe thrombocytopenia,and often accompanied by bleeding or thrombotic thrombocytopenic purpura(TTP),but the overall outcome is good.Platelet count should be regularly monitored within the first two weeks after medication.Clopidogrel should be stopped and symptomatic treatment should be given in case of any abnormality.
