Pharmaceutical Care for Tacrolimus-associated Posterior Reversible Encephalopathy Syndrome in A Pediatric Patient with Nephrotic Syndrome
10.3870/j.issn.1004-0781.2024.02.023
- VernacularTitle:1例肾病综合征患儿他克莫司相关可逆性后部脑病综合征的药学监护
- Author:
Leli TANG
1
,
2
;
Yidie HUANG
;
Xunjie ZHANG
;
Lin ZHU
;
Zhiping LI
Author Information
1. 国家儿童医学中心,复旦大学附属儿科医院临床药学部,上海 201102
2. 广东省珠海市妇幼保健院药学部,珠海 519000
- Keywords:
Tacrolimus;
Nephrotic syndrome;
Posterior reversible encephalopathy syndrome;
Pharmaceutical care
- From:
Herald of Medicine
2024;43(2):292-298
- CountryChina
- Language:Chinese
-
Abstract:
Objective To present a pharmaceutical care case of a pediatric patient with nephrotic syndrome developing tacrolimus-inducedposterior reversible encephalopathy syndrome(PRES)during tacrolimus treatment,and to accumulate experience for the treatment and pharmaceutical services of related diseases.Methods Clinical pharmacists conduct an analysis and evaluation of the correlation of drug-induced PRES caused by tacrolimus in a pediatric patient.Simultaneously,regarding the latest evidence-based information,they propose optimized drug therapy recommendations and provide personalized pharmaceutical services.Results After treatment with antispasmodics,blood pressure control,intracranial pressure reduction,and tapering of tacrolimus,the clinical symptoms of the child improved.Follow-up cranial MRI demonstrated partial absorption of abnormal signals in the brain,and the lesions were significantly smaller than before.Conclusion For tacrolimus-related PRES,clinical pharmacists can enhance the long-term safety and effectiveness of patient medication through aspects such as choosing antihypertensive drugs,adjusting treatment plans based on drug concentration monitoring,and implementing targeted pharmaceutical monitoring and educatio.
