Research Progress of Chinese Medicine Monomers with Anti-tumor Effect by Regulating Non-receptor Tyrosine Kinase
10.3870/j.issn.1004-0781.2024.01.017
- VernacularTitle:中药单体调控非受体型酪氨酸激酶抗肿瘤的研究进展
- Author:
Yujie HU
1
;
Lanyi WEI
;
Junjun CHEN
;
Yangyun ZHOU
;
Jiao YANG
;
Jiudong HU
;
Yonglong HAN
Author Information
1. 上海交通大学附属第六人民医院药剂科,上海 200233
- Keywords:
Traditional Chinese medicine monomers;
Non-receptor tyrosine kinase;
Tumor therapy
- From:
Herald of Medicine
2024;43(1):106-114
- CountryChina
- Language:Chinese
-
Abstract:
Cancer is a severe threat to human life and health.The over-activation of oncogenes is the main reason for poor treatment and prognosis of cancer patients.Most of these over-activated oncogenes are protein tyrosine kinase(PTK).Among many PTKs,non-receptor tyrosine kinase(NRTK)is an important signaling molecule that regulates cell proliferation and migration as the primary driver of intracellular signaling pathway transduction.Targeting NRTK has become the focus and difficulty in developing anti-tumor drugs.Traditional Chinese medicine(TCM),with its characteristics of multi-channel,multi-link,multi-target,and low toxicity,plays a significant advantage in treating adjuvant tumors.So far,it has been found various traditional TCM monomers can inhibit NRTK from playing an anti-tumor role.This review summarized the part of Src,Jak,Abl,Fak families,the prominent members of NRTK in tumor progression,as well as the TCM monomers acting on these members.We aimed to provide a theoretical basis for the anti-tumor therapy targeting NRTK and a reference for the search for TCM monomer inhibitors of NRTK.
