Research Progress of Bupivacaine Liposome Injection
10.3870/j.issn.1004-0781.2024.01.015
- VernacularTitle:布比卡因脂质体注射液研究进展
- Author:
Xin XU
1
;
Xiaohai WANG
;
Chunyan TANG
;
Jie CHEN
;
Weihong GE
Author Information
1. 南京大学医学院附属鼓楼医院麻醉科,南京 210008
- Keywords:
Bupivacaine liposome injection;
Long-acting preparation;
Liposome;
Postoperative analgesia
- From:
Herald of Medicine
2024;43(1):91-96
- CountryChina
- Language:Chinese
-
Abstract:
Bupivacaine is a long-acting local anesthetic widely used clinically,but its 6-8 hours duration is insufficient for postoperative analgesia.Designing drug dosage forms to prolong the action time of local anesthetics is the research content of local anesthetics.In 2011,the FDA approved a bupivacaine liposome preparation based on DepoFoam TM technology:Exparel,which can be used for more than 72 hours.This article reviewed the clinical safety research of Exparel and the research progress of its application in clinical postoperative analgesia.
