Analysis of 90 Cases of Serious Adverse Reactions Induced by Nedaplatin for Injection
10.3870/j.issn.1004-0781.2023.12.023
- VernacularTitle:注射用奈达铂致90例严重不良反应报告分析
- Author:
Fang TANG
1
;
Shupeng ZOU
;
Jinwen ZHANG
;
Yunzhou CHEN
Author Information
1. 华中科技大学同济医学院附属同济医院药学部,武汉 430030
- Keywords:
Nedaplatin for injection;
Serious adverse reactions;
Antineoplastic drug;
Adverse drug reaction;
Comprehensive report
- From:
Herald of Medicine
2023;42(12):1879-1882
- CountryChina
- Language:Chinese
-
Abstract:
Objective In order to discuss the rationality of clinical use of medication and the strategies of serious adverse reactions(SADR),the reports of SADRs caused by nedaplatin for injection were summarized and analyzed.Methods Methods Serious adverse reactions to all medicines reported to the National Adverse Reaction Monitoring Centre(NARMC)in Tongji Hospital Affiliated to Tongji Medical College,Huazhong University of Science and Technology from January 2012 to December 2021 were collected,and a retrospective analysis of 90 patients among those cases with SADR after nedaplatin injection was carried out.Results The occurrence of SADRs was not related to the gender.In monotherapy with nedaplatin,the rate of serious adverse effects was high with the first use of nedaplatin(74.3%).The incidence of adverse reactions was highest within 30 minutes and 2-14 days,including severe allergic reaction(34.4%)and grade Ⅱ-Ⅳ myelosuppression(51.2%),respectively.Drug withdrawal and symptomatic treatment were often the preferred treatment methods in clinical practice.Conclusion While using nedaplatin as a chemotherapy regimen,especially for the first time,patients should be closely monitored for the occurrence of severe anaphylaxis within 30 minutes and severe bone marrow suppression within 2 weeks.A rescue emergency plan for resuscitation and regular checking of the hemogram should be made to prevent the occurrence of serious adverse reactions.
