Clinical Application Advances of Antipsychotic Drugs in Female Schizophrenic Patients
10.3870/j.issn.1004-0781.2023.12.011
- VernacularTitle:女性精神分裂症患者的抗精神病药物临床应用进展
- Author:
Haoran XING
1
;
Xi ZHANG
;
Wenjing DING
;
Yingying ZHANG
;
Tianhao BAO
Author Information
1. 昆明医科大学附属精神卫生中心,云南省精神病医院老年科,昆明 650224
- Keywords:
Schizophrenia/Female;
Sex differences;
Antipsychotic drugs
- From:
Herald of Medicine
2023;42(12):1808-1812
- CountryChina
- Language:Chinese
-
Abstract:
Female patients with schizophrenia exhibit a slower rate of absorption and excretion,leading to higher blood levels of antipsychotic drugs in their bodies and consequently causing more drug side effects.Women also have different levels of estrogen at different stages of life,and estrogen improves the efficacy of antipsychotic drugs by increasing dopamine D2receptor sensitivity.It is necessary to adjust the dosage of antipsychotic medication based on the level of estrogen,while also monitoring indicators such as blood glucose,triglycerides,cholesterol,and prolactin to minimize medication side effects.Nevertheless,the current literatures do not provide specific treatment plans for schizophrenia tailored to different genders,which is not the optimal treatment strategy for female patients.This review aims to summarize and categorize the differences in prescription,pharmacokinetics,pharmacodynamics,efficacy,and side effects in female patients with schizophrenia,and to provide scientific recommendations for drug treatment strategies in different stages of a woman's life(premenopausal,pregnancy,lactation,postmenopausal).
