Effectiveness and Safety of Edaravone Combined with Oxiracetam in the Treatment of Acute Cerebral Infarction:A Meta-analysis
10.11969/j.issn.1673-548X.2024.01.012
- VernacularTitle:依达拉奉联合奥拉西坦治疗急性脑梗死疗效与安全性的Meta分析
- Author:
Shuai LIAN
1
;
Zhongliang MA
;
Yang LIU
Author Information
1. 450014 郑州大学第二附属医院脑血管病科
- Keywords:
Edaravone;
Oxiracetam;
Acute cerebral infarction;
Meta-analysis
- From:
Journal of Medical Research
2024;53(1):50-55
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effectiveness and safety of edaravone combined with oxiracetam in the treatment of acute cere-bral infarction.Methods PubMed,Embase,Cochrane Library,CNKI,Wanfang Data and other databases were comprehensively searched from database inception until October 27,2022,to collect randomized controlled trials of edaravone combined with oxiracetam in the treatment of acute cerebral infarction(ACI).RevMan5.4software was used to analyze the collected data.Results A total of9studies involving 887 patients were included.Meta-analysis results showed that the overall effective rate and Barthel index in the observation group were significantly higher than those in the control group(OR=4.66,95％CI:2.74-7.93,P＜0.001;MD=14.57,95％CI:8.58-20.56,P＜0.001),the NIHSS scores in the observation group were significantly lower than that in the control group(MD=-5.28,95％CI:-6.42--4.13,P＜0.001).There was no significant difference in adverse effect rate between the two groups(RR=1.11,95％CI:0.63-1.95,P=0.72).Conclusion The combination of edaravone and oxiracetam in the treatment of ACI can significantly reduce NIHSS scores,and improve Barthel index and overall effective rate.The efficacy is better than edaravone alone,and a more comprehensive evaluation of safety is needed in the future.
