Effect of Methylprednisolone on Elderly Patients Undergoing Percutaneous Balloon Kyphoplasty
10.11969/j.issn.1673-548X.2023.12.034
- VernacularTitle:甲泼尼龙对经皮球囊扩张椎体后凸成形术老年患者的影响
- Author:
Zehua ZHENG
1
;
Yuting JIN
;
Yu ZHANG
Author Information
1. 310000 杭州,浙江大学医学院附属第二医院麻醉手术部
- Keywords:
Geriatric orthopedic;
Spinal surgery;
Postoperative outcome;
Methylprednisolone
- From:
Journal of Medical Research
2023;52(12):172-176
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of methylprednisolone on elderly patients undergoing percutaneous balloon kyphoplasty(PKP).Methods A total of 180 elderly patients with PKP due to thoracolumbar fractures under general anesthesia were selected,and randomly divided into methylprednisolone 1mg/kg group(group M)and normal saline control group(group C),with 90 cases in each group.The pain visual analogue scale(VAS),blood glucose,C-reactive protein(CRP),white blood cell(WBC),percentage of neu-trophils,nausea and vomiting scores were recorded before operation,Postanesthesia Care Unit(PACU),2h and 1 day after operation.confusion assessment method(CAM)was used to evaluate the occurrence of postoperative delirium(POD)within 3days after operation,and the quality of life and mortality were assessed at 3months after follow-up.Results The blood glucose level of patients in group M in PACU was significantly higher than that in group C(P＜0.05),and the degree of nausea and the incidence of nausea and vomiting in PACU and 2h after operation(8.86％vs 23.38％)were significantly lower than those in group C(P＜0.05),and the degree of vomi-ting at 2h after operation was also lower than that in group C(P＜0.05).There was no significant difference in the incidence of POD be-tween the two groups within 3days after surgery(11.7％vs 12.7％)(P＞0.05).There was no significant difference in CRP,WBC,and neutrophil percentage between the two groups before operation and 1day after operation(P＞0.05).There was no significant difference in hospital stay,anesthesia cost and total medical cost between the two groups(P＞0.05).There was no significant difference in the 3-month mortality and quality of life score(SF-36)between the two groups(P＞0.05).Conclusion The intraoperative application of methylprednisolone can reduce the degree and incidence of postoperative nausea and vomiting in elderly patients with PKP,but it does not reduce the incidence of POD,and can lead to a transient increase in blood glucose level.
