Effect of Negative-pressure Wound Therapy with Irrigation Combined with Red and Blue Light on Diabetic Foot Wounds
10.11969/j.issn.1673-548X.2023.11.023
- VernacularTitle:负压滴灌治疗联合红蓝光对糖尿病足创面的疗效研究
- Author:
Haojie SUN
1
;
Houfa GENG
;
Lianjun DOU
Author Information
1. 221009 徐州市中心医院内分泌科、徐州医科大学徐州临床学院
- Keywords:
Diabetic foot;
Negative-pressure wound therapy with irrigation;
Red and blue light;
Wounds
- From:
Journal of Medical Research
2023;52(11):118-122
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect of negative-pressure wound therapy with irrigation(NPWTi)combined with red and blue light on diabetic foot wounds.Methods According to random number method,a total of 80 patients with type 2diabetes combined with diabetic foot admitted to Xuzhou Central Hospital from December 2021 to May 2022 were selected and divided into two groups:con-trol group and NPWTi + red and blue light group,with 40 cases in each group.All patients received basic treatment,while the control group received NPWTi treatment,NPWTi + red and blue light group was treated with red and blue light on the basis of NPWTi.The chan-ges of wound healing speed rate,serum inflammatory markers[erythrocyte sedimentation rate(ESR),C-reactive protein(CRP),pro-calcitonin(PCT)]and growth factors[vascular endothelial growth factor(VEGF),epidermal growth factor(EGF),basic fibroblast growth factor(bFGF)]were observed before and 7days after treatment.After 12 weeks of follow-up,the wound healing rate of the two groups were observed,and the cumulative wound healing rate of the two groups was evaluated through Kaplan-Meier curve.Results Af-ter 7days of treatment,the wound healing rate of NPWTi + red and blue light group was faster than that of the control group(P<0.01).The average levels of VEGF,EGF and bFGF in NPWTi + red blue light group were higher than those in the control group(P<0.05),while the average levels of ESR,CRP and,PCT in NPWTi + red and blue light group were lower than those in the control group(P<0.05).The wound healing rate of NPWTi + red and blue light group at 12 weeks was higher than that of the control group(P<0.05).Kaplan-Meier curve analysis showed that the cumulative wound healing rate of NPWTi + red and blue light group was higher than that of the control group(P<0.05).Conclusion NPWTi combined with red and blue light is effective in treating diabetic foot wounds,and it is worthy of clinical application.
