Clinical characteristics analysis of primary pancreatic lymphoma
10.3760/cma.j.cn115667-20231026-00051
- VernacularTitle:原发性胰腺淋巴瘤临床特征分析
- Author:
Yinghao SUN
1
;
Jianing LI
;
Kun HE
;
Liang ZHU
;
Yunlu FENG
;
Qiang WANG
;
Qingwei JIANG
;
Yan ZHANG
;
Qiang XU
;
Zheng WANG
;
Jingya ZHOU
;
Dong WU
Author Information
1. 中国医学科学院北京协和医院消化内科，北京 100730
- Keywords:
Primary pancreatic lymphoma;
Lymphoma, large B-cell, diffuse;
Lactate dehydrogenase;
Endoscopic ultrasound-guided fine needle aspiration
- From:
Chinese Journal of Pancreatology
2024;24(1):52-56
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze clinical characteristics of primary pancreatic lymphoma (PPL) patients.Methods:Clinical features of 22 patients diagnosed as PPL admitted to Peking Union Medical College Hospital from January 2002 to May 2023 were analyzed retrospectively.Results:The median age was 56.4±13.3 years. The median time from onset to diagnosis was 1.0 (1.0, 3.0) months. The main clinical manifestations were abdominal pain (15/22), weight loss (14/22) and jaundice (10/22). Elevated lactate dehydrogenase (LDH) was observed in 15/20 (75%) patients. Only 2 (2/9, 22.2%) patients had increased CA199 levels and 2 (2/9, 22.2%) patients had increased CEA levels. The maximum tumor diameter was 5.0 (3.8, 6.9) cm. Contrast-enhanced CT mostly showed low enhancement lesions. Major pancreatic duct dilatation were rare on CT scan (4/20). Fifteen patients were confirmed by pancreatic pathology, of which 8 were obtained by surgery, 4 were obtained by CT or ultrasound-guided percutaneous biopsy, and 3 were obtained by EUS-FNA. The main pathological type was diffuse large B-cell lymphoma (14/22). 19 patients received chemotherapy, and 6 patients died with a median follow-up of 5.0 (1.5, 35.5) months.Conclusions:PPL is rare and easy to be misdiagnosed. Elevated LDH levels, normal tumor markers, and non-dilatation of main pancreatic duct are important diagnostic clues. It is important to obtain pathology by EUS-FNA and other methods for definite diagnosis.
