A Case of Microscopic Polyangiitis Associated with Paranasal Sinusitis and Pulmonary Hemorrhage.
- Author:
Hee Kyoo KIM
1
;
Ho Sik SHIN
;
Yeon Soon JUNG
;
Ji Ho KO
;
Chul Ho OAK
;
Tae Won JANG
;
Hark RIM
;
Maan Hong JUNG
Author Information
1. Department of Internal Medicine, College of Medicine, Kosin University, Gospel Hospital, Busan, Korea. kongpot@medimail.co.kr
- Publication Type:Original Article
- Keywords:
Microscopic polyangiitis;
Perinuclear antineutrophil cytoplasmic antibodies;
Vasculitis;
Pulmonary hemorrhage;
Sinusitis
- MeSH:
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis;
Antibodies, Antineutrophil Cytoplasmic;
Biopsy;
Cyclophosphamide;
Dyspnea;
Female;
Glomerulonephritis;
Hemoptysis;
Hemorrhage*;
Humans;
Methylprednisolone;
Microscopic Polyangiitis*;
Middle Aged;
Prednisolone;
Renal Insufficiency;
Sepsis;
Sinusitis*;
Tablets;
Thorax;
Tomography, X-Ray Computed;
Vasculitis
- From:Korean Journal of Nephrology
2005;24(5):832-837
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Microscopic polyangiitis is a systemic small-vessel vasculitis primarily associated with necrotizing glomerulonephritis and pulmonary capillaritis. This disease is determined by clinical manifestation, ANCA, and involved organ or renal biopsy. We describe a 49-year-old female presenting with chronic postnasal drip, progressive dyspnea and abrupt hemoptysis. Her serum p-ANCA was postitive, but c- ANCA was negative. Her chest X-ray and chest CT scan showed pulmonary hemorrhage, and the renal biopsy specimen revealed crescentic glomerulonephritis. She was diagnosed as having an ANCA-associated vasculitis, and more specifically, a microscopic polyangiitis accompanied with paranasal sinusitis. She was treated with intravenous methylprednisolone pulse therapy, followed by prednisolone and cyclophosphamide per oral tablets. She showed rapid progression of renal failure and died from sepsis after 2 months of treatment.
