A Case of Allopurinol Hypersensitivity Syndrome in a Patient with Chronic Renal Failure.
- Author:
Min Kuk KIM
1
;
Seung Hee YOO
;
Soo Sung OH
;
Young Soo KIM
;
Sun Ae YOON
;
Young Ok KIM
;
Yoon Sik CHANG
;
Jin Wou KIM
Author Information
1. Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea. cmckyo@yahoo.co.kr
- Publication Type:Case Report
- Keywords:
Allopurinol;
Hypersensitivity;
Renal failure;
Toxic epidermal necrosis
- MeSH:
Adult;
Allopurinol*;
Biopsy;
Chemistry;
Exanthema;
Fever;
Glomerulonephritis;
Humans;
Hypersensitivity*;
Hyperuricemia;
Kidney Failure, Chronic*;
Male;
Renal Dialysis;
Renal Insufficiency;
Skin;
Stevens-Johnson Syndrome
- From:Korean Journal of Nephrology
2005;24(5):851-855
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Allopurinol hypersensitivity syndrome is a rare but life-threatening complication. We here report a case of allopurinol hypersensitivity syndrome manifested with irreVersible change of renal function and severe toxic epidermal necrolysis in a patient with chronic renal faiure. A 29-year-old male patient with chronic renal failure due to chronic glomerulonephritis presented with high fever and skin rash. He had been taking allopurinol for 6 weeks due to asymptomatic hyperuricemia. Blood chemistry showed severe hepatic dysfunction and aggrevated renal function. Skin biopsy revealed consistent findings with allopurinol hypersenstivity syndorme. Allopurinol was discontinued and steroid was instituted. His cutaneous lesion and high fever, and hepatic dysfunction improved but renal function irreversibly progressed in end stage renal failure requiring maintenance hemodialysis treatment.