Association of PPIs use with short-term and long-term mortality risk in patients with severe ischemic stroke:a retrospective cohort study based on the MIMIC-Ⅲ database
10.12173/j.issn.1005-0698.202306088
- VernacularTitle:PPIs与重症缺血性脑卒中患者短期、长期死亡风险的关联:基于MIMIC-Ⅲ数据库的回顾性队列研究
- Author:
Sisi QIN
1
;
Huitao ZHANG
;
Haiyan PAN
;
Yaoli ZHU
;
Li ZENG
Author Information
1. 中山大学附属第五医院重症医学科(广东珠海 519000)
- Keywords:
Proton pump inhibitors;
Severe ischemic stroke;
Mortality risk;
MIMIC-Ⅲ database
- From:
Chinese Journal of Pharmacoepidemiology
2024;33(1):45-51
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association of proton pump inhibitors(PPIs)use with short-term and long-term mortality risk in patients with severe ischemic stroke.Methods This retrospective study based on the U.S.Medical Information Mark for Intensive Care Ⅲ(MIMIC-Ⅲ)database,ICU patients aged ≥18 years with the first ICU admission and a diagnosis of ischemic stroke were finally included in the study.All enrolled subjects were divided into PPIs group and non-PPIs group according to whether they had used PPIs(pantoprazole,lansoprazole and omeprazole)during hospitalization.Kaplan-Meier survival analyses and Cox regression models were used to analyze the association between the use of PPIs and the risk of ICU death,30 d risk of death,90 d risk of death in patients with severe ischemic stroke.Results A total of 1 015 patients were included,402 cases in the PPIs group and 613 in the non-PPIs group.The ICU-mortality,30 d and 90 d mortality were 15.37％,13.60％and 20.10％,respectively.Kaplan-Meier survival analyses illustrated that the PPIs group survived better than non-PPIs group in ICU mortality analysis(P=0.002).In Cox regression analysis,after adjustment for potential confounders,the hazard ratio(HR)for ICU mortality in the PPIs group relative to the non-PPIs group was 0.671 9(95％CI 0.478 8 to 0.942 8,P=0.021),but there was no significant difference between 30 d and 90 d mortality(P＞0.05).Conclusion In patients with severe ischemic stroke,the use of PPIs may be effective in reducing the risk of ICU death,but does not improve 30 d and 90 d risk of death in patients.
