A Case of Acute Theophylline Intoxication Treated with Hemoperfusion.
- Author:
Jung Hwan LEE
1
;
Woong Sik OH
;
Sung Woo PARK
;
Seong Tae RYU
;
Keong Wook KIM
Author Information
1. Department of Internal Medicine, Kwang Myung Sung Ae Hospital, Kwang Myung, Korea. nek2w@hanmail.net
- Publication Type:Case Report
- Keywords:
Theophylline;
Hypotension;
Tachycardia;
Hemoperfusion
- MeSH:
Anoxia;
Asthma;
Blood Pressure;
Dopamine;
Dyspnea;
Eating;
Gastric Lavage;
Heart Rate;
Hemoperfusion*;
Humans;
Hypotension;
Intention;
Male;
Midazolam;
Middle Aged;
Plasma;
Seizures;
Stupor;
Tachycardia;
Theophylline*
- From:Korean Journal of Nephrology
2005;24(5):860-863
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Theophylline has been used for more than 50 years to treat bronchial asthma, and theophylline toxicity continues to be an encountered clinical problem. With suicidal intention, a 61-year-old depressive male patient was sent to the hospital after ingestion of overdose theophylline. He had been followed up for bronchial asthma with about 10 microgram/ mL average plasma theophylline level. On arrival, he complained of dyspnea, palpitation and the plasma theophylline level was 252 microgram/mL. After 2 hours of ingestion, hypotension and tachycardia developed (Systolic blood pressure 50 mmHg, heart rate 190/ min). Other symptoms and signs were stuporous mental state and hypoxemia. Patient's peak plasma theophylline level reached 402 microgram/mL after 3 hours. beta-blocker, dopamine and midazolam were used for control of tachycardia, hypotension and prevention of seizure respectively. After Gastric lavage and administration of charchoal, he was treated with hemoperfusion for 3.5 hours, and serum level decreased. The patient was discharged in good health after 17 days.