Lipid metabolism analysis in esophageal cancer and associated drug discovery
10.1016/j.jpha.2023.08.019
- Author:
Ruidi JIAO
1
,
2
;
Wei JIANG
;
Kunpeng XU
;
Qian LUO
;
Luhua WANG
;
Chao ZHAO
Author Information
1. Bionic Sensing and Intelligence Center,Institute of Biomedical and Health Engineering,Shenzhen Institute of Advanced Technology,Chinese Academy of Sciences,Shenzhen,Guangdong,518000,China
2. Department of Radiation Oncology,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital&Shenzhen Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Shenzhen
- Keywords:
Lipid metabolism;
Esophageal cancer;
Progression;
Treatment resistance;
New therapeutic targets
- From:
Journal of Pharmaceutical Analysis
2024;14(1):1-15
- CountryChina
- Language:Chinese
-
Abstract:
Esophageal cancer is an upper gastrointestinal malignancy with a bleak prognosis.It is still being explored in depth due to its complex molecular mechanisms of occurrence and development.Lipids play a crucial role in cells by participating in energy supply,biofilm formation,and signal transduction pro-cesses,and lipid metabolic reprogramming also constitutes a significant characteristic of malignant tu-mors.More and more studies have found esophageal cancer has obvious lipid metabolism abnormalities throughout its beginning,progress,and treatment resistance.The inhibition of tumor growth and the enhancement of antitumor therapy efficacy can be achieved through the regulation of lipid metabolism.Therefore,we reviewed and analyzed the research results and latest findings for lipid metabolism and associated analysis techniques in esophageal cancer,and comprehensively proved the value of lipid metabolic reprogramming in the evolution and treatment resistance of esophageal cancer,as well as its significance in exploring potential therapeutic targets and biomarkers.
