Metabolomics Insights Into Pathophysiological Mechanisms of Interstitial Cystitis.
10.5213/inj.2014.18.3.106
- Author:
Oliver FIEHN
1
;
Jayoung KIM
Author Information
1. West Coast Metabolomics Center, University of California, Davis, Davis, CA, USA.
- Publication Type:Review
- Keywords:
Interstitial cystitis;
Metabolomics;
Biological markers;
Magnetic resonance spectroscopy;
Mass spectrometry
- MeSH:
Bacterial Infections;
Biomarkers;
Cystitis, Interstitial*;
Dermatoglyphics;
Early Diagnosis;
Magnetic Resonance Spectroscopy;
Mass Spectrometry;
Metabolome;
Metabolomics*;
Pelvic Pain;
Quality of Life;
Urinary Bladder;
Urinary Tract
- From:International Neurourology Journal
2014;18(3):106-114
- CountryRepublic of Korea
- Language:English
-
Abstract:
Interstitial cystitis (IC), also known as painful bladder syndrome or bladder pain syndrome, is a chronic lower urinary tract syndrome characterized by pelvic pain, urinary urgency, and increased urinary frequency in the absence of bacterial infection or identifiable clinicopathology. IC can lead to long-term adverse effects on the patient's quality of life. Therefore, early diagnosis and better understanding of the mechanisms underlying IC are needed. Metabolomic studies of biofluids have become a powerful method for assessing disease mechanisms and biomarker discovery, which potentially address these important clinical needs. However, limited intensive metabolic profiles have been elucidated in IC. The article is a short review on metabolomic analyses that provide a unique fingerprint of IC with a focus on its use in determining a potential diagnostic biomarker associated with symptoms, a response predictor of therapy, and a prognostic marker.
