Promise of spatially resolved omics for tumor research
10.1016/j.jpha.2023.07.003
- Author:
Yanhe ZHOU
1
;
Xinyi JIANG
;
Xiangyi WANG
;
Jianpeng HUANG
;
Tong LI
;
Hongtao JIN
;
Jiuming HE
Author Information
1. State Key Laboratory of Bioactive Substance and Function of Natural Medicines,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,100050,China
- Keywords:
Tumor;
Spatially resolved transcriptomics;
Spatially resolved metabolomics
- From:
Journal of Pharmaceutical Analysis
2023;13(8):851-861
- CountryChina
- Language:Chinese
-
Abstract:
Tumors are spatially heterogeneous tissues that comprise numerous cell types with intricate structures.By interacting with the microenvironment,tumor cells undergo dynamic changes in gene expression and metabolism,resulting in spatiotemporal variations in their capacity for proliferation and metastasis.In recent years,the rapid development of histological techniques has enabled efficient and high-throughput biomolecule analysis.By preserving location information while obtaining a large number of gene and molecular data,spatially resolved metabolomics(SRM)and spatially resolved transcriptomics(SRT)approaches can offer new ideas and reliable tools for the in-depth study of tumors.This review provides a comprehensive introduction and summary of the fundamental principles and research methods used for SRM and SRT techniques,as well as a review of their applications in cancer-related fields.
