Relationship between intestinal flora and acute respiratory distress syndrome in patients with severe acute pancreatitis
10.3760/cma.j.cn115455-20220426-00362
- VernacularTitle:重症急性胰腺炎患者肠道菌落情况与其并发急性呼吸窘迫综合征的关系分析
- Author:
Wei GUO
1
;
Yan LOU
;
Jinli ZHANG
;
Hangjie WU
Author Information
1. 浙江省医疗健康集团杭州医院重症医学科，杭州 310000
- Keywords:
Pancreatitis;
Respiratory distress syndrome, adult;
Severe;
Intestinal colony
- From:
Chinese Journal of Postgraduates of Medicine
2024;47(1):44-47
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the relationship between intestinal flora and acute respiratory distress syndrome in patients with severe acute pancreatitis.Methods:One hundred and six patients with severe acute pancreatitis admitted to a hospital from March 2019 to February 2021 were selected as the observation group for prospective analysis. They were divided into concurrent group (52 cases) and non-concurrent group (54 cases) according to whether they were complicated with acute respiratory distress syndrome. In addition, 100 healthy people in the same period were selected as the control group to analyze the relationship between intestinal flora and acute respiratory distress syndrome in patients with severe acute pancreatitis.Results:There were significant differences in the number of intestinal flora ( Lactobacillus, Bifidobacterium, Escherichia coli) between the observation group and the control group ( t = 49.69, 73.28 and 46.32; P<0.05). There were significant differences in the number of intestinal flora ( Lactobacillus, Bifidobacterium, Escherichia coli) between the concurrent group and the non-concurrent group ( t = 34.85, 39.71 and 23.47; P<0.05). The levels of serum endotoxin, diamine oxidase and D-lactic acid in the concurrent group were significantly higher than those in the non-concurrent group: (0.63 ± 0.16) EU/ml vs. (0.45 ± 0.08) EU/ml, (6.29 ± 1.18) U/ml vs. (4.89 ± 0.91) U/ml, (11.63 ± 2.84) mmol/L vs. (9.33 ± 2.61) mmol/L ( t = 7.37, 6.85 and 4.34, P<0.05). Spearman analysis showed that severe acute pancreatitis complicated with acute respiratory distress syndrome was negatively correlated with the number of intestinal Lactobacillus and Bifidobacterium ( r = - 0.342 and - 0.291, P = 0.011 and 0.021), which was positively correlated with the number of intestinal Escherichia coli flora ( r = 0.263, P = 0.033). Conclusions:Intestinal colony imbalance is common in patients with severe acute pancreatitis, and the imbalance of intestinal colony and the impairment of intestinal mucosal barrier function are more serious in patients with acute respiratory distress syndrome. There is a significant correlation between severe acute pancreatitis complicated with acute respiratory distress syndrome and its intestinal colony.
