Effects of butorphanol pretreatment on dexamethasone-induced discomfort symptoms
10.3760/cma.j.cn115455-20221031-00940
- VernacularTitle:布托啡诺预处理对于地塞米松引起会阴部不适症状的影响
- Author:
Yilin GUAN
1
;
Tao JIANG
;
Ling ZHAO
;
Min LI
;
Baojie MA
Author Information
1. 大连市妇女儿童医疗中心（集团）麻醉科，大连 116000
- Keywords:
Butorphanol;
Dexamethasone;
Perineum;
Discomfort symptoms
- From:
Chinese Journal of Postgraduates of Medicine
2023;46(12):1091-1094
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of pretreatment with butorphanol on perineal discomfort caused by intravenous injection of dexamethasone sodium phosphate.Methods:Using the method of prospective study, ninety patients undergoing elective gynecological surgery in Dalian Women And Children′s Medical Group from June to December 2021 were randomly divided into three groups: butorphanol 0.5 mg pretreatment group (group B1), butorphanol 1.0 mg pretreatment group (group B2) and normal saline control group (group C), with 30 cases in each group. Patients in groups B1 and B2 were given butorphanol 0.5 mg and 1.0 mg intravenously, respectively, prior to induction of anesthesia, while those in group C were given 0.9% sodium chloride injection. 3 minutes later, all patients in the three groups were given dexamethasone sodium phosphate injection 10 mg, and the incidence, grade and adverse reactions of their perineal discomfort symptoms were recorded.Results:The incidence of perineal discomfort and moderate perineal discomfort of patients in group B1 and group B2 was lower than that in group C: 20.00%(6/30)and 10.00%(3/30)vs. 60.00%(18/30), 3.33%(1/30)and 3.33(1/30)vs. 30.00%(10/30), with a statistically significant differences ( P<0.05). The incidence of adverse reactions such as dizziness was increased in the group B2:26.67%(8/30)and 10.00%(3/30)vs. 40.00%(12/30), with a statistically significant difference ( χ2 = 7.13, P = 0.028). Conclusions:Butorphanol 0.5 mg and 1.0 mg pretreatments are touted as effective in inhibiting perineal discomfort caused by intravenous injection of dexamethasone sodium phosphate. However, the butorphanol 0.5 mg pretreatment group have fewer adverse reactions.
